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상품명 | Poly(D,L-lactide-co-glycolide), 50:50, IV 0.4 dl/g, acid-terminated |
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판매가 | 견적문의 |
월 렌탈 금액 |
월 원 (개월 기준)
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(최소주문수량 1개 이상 / 최대주문수량 0개 이하)
사이즈 가이드상품명 | 상품수 | 가격 |
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Poly(D,L-lactide-co-glycolide), 50:50, IV 0.4 dl/g, acid-terminated | 수량증가 수량감소 | 견적문의 ( ) |
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할인가가 적용된 최종 결제예정금액은 주문 시 확인할 수 있습니다.
Poly(DL-lactide-co-glycolide) (PLGA) is a well-established biodegradable polymer used in medical devices and drug delivery applications. In comparison to poly(L-lactide) (PLLA), PLGA offers control over degredation rate and reduced glass transition temperatures (by increasing glycolide content).1 The control of these properties makes PLGA especially well suited for applications where medical devices are only needed for weeks (e.g. drug
Acid-terminated PLGA allows for easy conjugation to drugs with nucleophilic functionalities.4
SYNONYMS: PDLGA, PLGA, DL-PLGA
1. Middleton, John C., and Arthur J. Tipton. 2000. "Synthetic Biodegradable Polymers as Orthopedic Devices.” Biomaterials 21 (23): 2335–46. doi:10.1016/S0142-9612(00)00101-0.
2. Grayson, Amy C Richards, Insung S Choi, Betty M Tyler, Paul P Wang, Henry Brem, Michael J Cima, and Robert Langer. 2003. “Multi-Pulse Drug Delivery from a Resorbable Polymeric Microchip Device.” Nature Materials 2 (11). Nature Publishing Group: 767–72. doi:10.1038/nmat998.
3. Dawes, G J S, L E Fratila-Apachitei, K Mulia, I Apachitei, G-J Witkamp, and J Duszczyk. 2009. “Size Effect of PLGA Spheres on Drug Loading Efficiency and Release Profiles.” Journal of Materials Science: Materials in Medicine 20 (5). Springer: 1089–94. doi:10.1007/s10856-008-3666-0.
4. Crucho, Carina I C, and Maria Teresa Barros. 2015. “Formulation of Functionalized PLGA Polymeric Nanoparticles for Targeted Drug Delivery.” Polymer 68 (June): 41–46. doi:http://dx.doi.org/10.1016/j.polymer.2015.04.083.
FTIR: conforms
INHERENT VISCOSITY (ΗINH): 0.30 - 0.50 dL/g (25°C; CHCl3; 0.5 g/dL)
ACID NUMBER: ≥ 3 (mg KOH)/g
LACTIDE/GLYCOLIDE : 45-55/45-55 (mol%) (NMR)
VISCOSITY MOLECULAR WEIGHT (MΗ): 22,000 - 45,000
GLASS TRANSITION TEMP. (TG): 45-50°C 1
SOLUBLE IN: dichloromethane (DCM), tetrahydrofuran (THF), ethyl acetate, acetone
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