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Poly(ε-caprolactone)-block-poly(ethylene glycol)-orthopyridyl disulfide (PCL-PEG-OPSS) is a functional amphiphilic block copolymer which has orthopyridyl disulfide group at PEG end.Orthopyridyl disulfide or pyridyldithio functional group can selectively reacts with free thiol, SH, sulfhydryl or mercapto to form a oxidation, reduction reversible disulfide bond. Micelles or nanoparticles from PCL-PEG-OPSS can be modifed via OPSS for targeted drug delivery.
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