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Azide-polyethylene glycol-Hydroxyl (N3-PEG-OH) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials via Click Chemistry. Azide group can react with alkyne in aqueous solution catalyzed by copper, and hydroxly group can react with COOH group from a peptide. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.
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